Itopride hydrochloride

Research use only, not for human use.

Itopride hydrochloride is an AChE inhibitor (acetylcholinesterase) and D2DR inhibitor.

Itopride hydrochloride is an AChE inhibitor (acetylcholinesterase) and D2DR inhibitor. (In Vitro):Itopride hydrochloride has prokinetic effects on both the ileum and colon, which are regulated through inhibitory effects on AChE and antagonistic effects on dopamine D2 receptor.Itopride hydrochloride (0.1 nM-1 μM) significantly accelerats the propagation velocity of the peristalsis in ex guinea pig ileum.(In Vivo):Itopride hydrochloride (30 mg/kg; p.o.) significantly accelerates gastric emptying compared with the vehicle group.Itopride hydrochloride (30 mg/kg; p.o.) displays Cmax of 358 ‰, T1/2 of 24.9 min.

Itopride hydrochloride has prokinetic effects on both the ileum and colon, which are regulated through inhibitory effects on AChE and antagonistic effects on dopamine D2 receptor.Itopride hydrochloride (0.1 nM-1 μM) significantly accelerats the propagation velocity of the peristalsis in ex guinea pig ileum.

Itopride hydrochloride (30 mg/kg; p.o.) significantly accelerates gastric emptying compared with the vehicle group.Itopride hydrochloride (30 mg/kg; p.o.) displays Cmax of 358 ‰, T1/2 of 24.9 min. Animal Model:Male ddY-strain mice (23.7-28.5 g)Dosage:3 mg/kg, 10 mg/kg, 30 mg/kg Administration:Oral administration Result:Accelerated gastric emptying at 30 mg/kg dose.Animal Model:Male ddY-strain mice (23.7-28.5 g)Dosage:3 mg/kg, 10 mg/kg, 30 mg/kg (Pharmacokinetic Analysis)Administration:Oral administrationResult:Cmax (358 ‰), T1/2 (24.9 min) at 30 mg/kg dose.

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Endocrinology/Hormones

AChR

AChE

Neurological Disease

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122892-31-3

394.9

C20H27CLN2O4

>98% (HPLC)

DMSO: 52mg/mL

Cl.COC1=C(OC)C=C(C=C1)C(=O)NCC1=CC=C(OCCN(C)C)C=C1

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(-20℃)

With Ice Pack

≥ 2 years